You’ll begin to notice enhancements shortly after your first session, with the full effect gradually emerging over the following 12 weeks. The treatment works by prompting your skin’s own repair mechanisms: it activates fibroblasts to boost collagen and hydration, delivers antioxidants that help neutralize free radicals, and encourages overall repair processes that refine scars, stretch marks, pigmentation, and texture. The degree of improvement will depend on factors like your age, lifestyle, treatment frequency, and your skin’s inherent ability to produce collagen and elastin.

This therapy is considered safe when performed by a skilled practitioner and is suitable for a wide range of skin types, tones, and ages. It is especially beneficial for those looking to rejuvenate the under-eye area, diminish acne scars, balance uneven pigmentation, or counter signs of aging on the lower face and neck—making it a good alternative for patients who aren’t ideal candidates for tear trough fillers. However, it is not recommended for pregnant or breastfeeding individuals, nor for those adhering to vegan or vegetarian lifestyles, as the active ingredients are derived from salmon or trout DNA.

The effects typically endure for about 6 to 9 months. To maintain optimal skin quality, we advise scheduling a maintenance session every 6 to 12 months, as the natural aging process continues despite the collagen boost.

You might notice very small bumps at the injection sites immediately after treatment; however, these minor elevations usually fade within one to two days and are not associated with significant redness or irritation.

Polynucleotide injections have an exceptional safety record. Since the product is water-based, there is no risk of vascular blockage or puffiness. The salmon-derived DNA is highly purified and is generally well tolerated—even by those with fish allergies. This treatment does not promote abnormal cell activity or raise skin cancer risks; in fact, it helps stabilize pigment cells, aiding in the reduction of pigmentation issues. Any side effects are typically limited to brief, mild redness, swelling, or bruising at the injection sites.

The procedure is virtually painless, thanks to the use of ultra-fine needles and numbing cream. Most patients experience little to no discomfort during the injections.

Avoid blood-thinning medications (aspirin, ibuprofen) and supplements (fish oil, vitamin E, ginkgo biloba) for 48 hours before treatment.

• Refrain from alcohol for 24 hours prior.

• Arrive with clean, makeup-free skin (especially around the eyes, if applicable).

• Avoid other facial treatments (chemical peels, laser, micro-needling) for two weeks before your appointment.

• Stay well-hydrated.

Do not touch, rub, or massage treated areas for 24 hours.

• Avoid makeup on treated areas for at least 4 hours.

• Gently cleanse your face in the evening using a mild cleanser (avoid retinols and acids on the first night).

• Avoid strenuous exercise, saunas, or heat exposure for 48 hours.

• If swelling occurs, apply a cold compress gently (without pressure).

• Protect your skin from sun exposure and avoid tanning beds for at least one week.